Recent advances in drug discovery for diabetic kidney disease

被引:11
|
作者
Danta, Chhanda Charan [1 ]
Boa, Andrew N. [2 ]
Bhandari, Sunil [3 ,4 ]
Sathyapalan, Thozhukat [5 ]
Xu, Shang-Zhong [1 ,5 ]
机构
[1] Univ Hull, Hull York Med Sch, Ctr Atherothrombosis & Metab Dis, Kingston Upon Hull HU6 7RX, N Humberside, England
[2] Univ Hull, Dept Chem, Kingston Upon Hull, N Humberside, England
[3] Hull Univ Teaching Hosp NHS Trust, Hull Royal Infirm, Dept Renal Med, Kingston Upon Hull, N Humberside, England
[4] Hull Univ Teaching Hosp NHS Trust, Hull Royal Infirm, Hull York Med Sch, Kingston Upon Hull, N Humberside, England
[5] Univ Hull, Hull York Med Sch, Acad Diabet Endocrinol & Metab, Kingston Upon Hull, N Humberside, England
基金
欧盟地平线“2020”;
关键词
Diabetic complications; diabetic nephropathy; drug discovery; endothelin receptor blockers; oxidative stress; renin-angiotensin-aldosterone system; SGLT-2; inhibitors; GLOMERULAR ENDOTHELIAL GLYCOCALYX; COTRANSPORTER; 2; INHIBITION; TO-MESENCHYMAL TRANSITION; BASE-LINE CHARACTERISTICS; OXIDATIVE STRESS; RENAL FIBROSIS; BLOOD-PRESSURE; NITRIC-OXIDE; NEPHROPATHY; PROGRESSION;
D O I
10.1080/17460441.2021.1832077
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectiveness or clinical usefulness of such treatment has not been well validated. Therefore, searching for new targets and potential therapeutic candidates has become an emerging research area. Areas covered The pathophysiological mechanisms, new drug targets and potential therapeutic compounds for DKD are addressed in this review. Expert opinion Although preclinical and clinical evidence has shown some positive results for controlling DKD progression, treatment regimens have not been well developed to reduce the mortality in patients with DKD globally. Therefore, the discovery of new therapeutic targets and effective target-based drugs to achieve better and safe treatment are urgently required. Preclinical screening and clinical trials for such drugs are needed.
引用
收藏
页码:447 / 461
页数:15
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