Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids

被引：32
作者：
Melzig, MF
机构：
[1] Institute of Molecular Pharmacology, D-10315 Berlin
来源：
PLANTA MEDICA | 1996年 / 62卷 / 01期
关键词：
flavonoids; adenosine deaminase; endothelial cells; adenosine; pharmacology;
D O I：
10.1055/s-2006-957788
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Flavonols like quercetin, myricetin, and kaempferol inhibit the activity of the adenosine deaminase of endothelial cells (IC50 between 26 and 32 mu mol/l), while flavones are inactive. These results support the suggestion that many pharmacological actions of flavonoids are mediated by an amplification of the effect of endogenous adenosine via adenosine receptors because adenosine deaminase is responsible for the adenosine inactivation.
引用
收藏
页码：20 / 21
页数：2
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