Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Knowledge of the use, methods of application, and adverse effects of hyaluronidases is essential for the aesthetic practitioner. Therefore, we performed an extensive review of the available literature from 1928 to 2011 and compared the different enzymes available, recording each author's indications regarding usage and side effects.
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Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Miami, Dept Otolaryngol, Div Facial Plast & Reconstruct Surg, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Grunebaum, Lisa Danielle
;
Allemann, Inja Bogdan
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Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Zurich Hosp, Dermatol Clin, CH-8091 Zurich, SwitzerlandUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Allemann, Inja Bogdan
;
Dayan, Steven
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Univ Illinois, Dept Otolaryngol, Chicago, IL USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Dayan, Steven
;
Mandy, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Dept Dermatol, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Mandy, Stephen
;
Baumann, Leslie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Miami, Dept Dermatol, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Kim, Deok-Woo
;
Yoon, Eul-Sik
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Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Yoon, Eul-Sik
;
Ji, Yi-Hwa
论文数: 0引用数: 0
h-index: 0
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Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Ji, Yi-Hwa
;
Park, Seung-Ha
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Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Park, Seung-Ha
;
Lee, Byung-Il
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Lee, Byung-Il
;
Dhong, Eun-Sang
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Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
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CHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Kim, Tae Wan
;
Lee, Jae Hoon
论文数: 0引用数: 0
h-index: 0
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CHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Lee, Jae Hoon
;
Yoon, Kyung Bong
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Anesthesia & Pain Res Inst, Dept Anesthesiol & Pain Med, 134 Shinchon Dong, Seoul 120752, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Yoon, Kyung Bong
;
Yoon, Duck Mi
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Anesthesia & Pain Res Inst, Dept Anesthesiol & Pain Med, 134 Shinchon Dong, Seoul 120752, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
机构:
Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Miami, Dept Otolaryngol, Div Facial Plast & Reconstruct Surg, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Grunebaum, Lisa Danielle
;
Allemann, Inja Bogdan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Zurich Hosp, Dermatol Clin, CH-8091 Zurich, SwitzerlandUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Allemann, Inja Bogdan
;
Dayan, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Otolaryngol, Chicago, IL USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Dayan, Steven
;
Mandy, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Dept Dermatol, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Mandy, Stephen
;
Baumann, Leslie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
Univ Miami, Dept Dermatol, Miami Beach, FL 33140 USAUniv Miami, Cosmet Med & Res Inst, Miami Beach, FL 33140 USA
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Kim, Deok-Woo
;
Yoon, Eul-Sik
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Yoon, Eul-Sik
;
Ji, Yi-Hwa
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Ji, Yi-Hwa
;
Park, Seung-Ha
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Park, Seung-Ha
;
Lee, Byung-Il
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
Lee, Byung-Il
;
Dhong, Eun-Sang
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South KoreaKorea Univ, Dept Plast & Reconstruct Surg, Med Ctr, Ansan 425707, Gyeonggi Do, South Korea
机构:
CHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Kim, Tae Wan
;
Lee, Jae Hoon
论文数: 0引用数: 0
h-index: 0
机构:
CHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Lee, Jae Hoon
;
Yoon, Kyung Bong
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Anesthesia & Pain Res Inst, Dept Anesthesiol & Pain Med, 134 Shinchon Dong, Seoul 120752, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea
Yoon, Kyung Bong
;
Yoon, Duck Mi
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Anesthesia & Pain Res Inst, Dept Anesthesiol & Pain Med, 134 Shinchon Dong, Seoul 120752, South KoreaCHA Univ, Coll Med, CHA Bundang Med Ctr, Dept Anesthesiol & Pain Med, Seongnam, South Korea