Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods

被引：21

作者：

Liu, Jun ^{[1
]}

Pan, Jianke ^{[2
]}

Wang, Yanping ^{[3
]}

Lin, Dingkun ^{[1
]}

Shen, Dan ^{[4
]}

Yang, Hongjun ^{[4
]}

Li, Xiang ^{[1
]}

Luo, Minghui ^{[1
]}

Cao, Xuewei ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, Guangzhou 510120, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Sch Clin Med 2, Guangzhou 510405, Guangdong, Peoples R China

[3] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China

[4] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2013年 / 33卷 / 05期

基金：

高等学校博士学科点专项科研基金;

关键词：

Knee osteoarthritis; Fuming-washing therapy; Drug prescriptions; Data mining;

D O I：

10.1016/S0254-6272(14)60043-1

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis (KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods. METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, and new prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively. RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found. Five new fuming-washing recipes for KOA were developed. CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs, and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing. therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao (Herba Speranskiae Tuberculatae), Honghua (Flos Carthami), Niuxi (Radix Achyranthis Bidentatae), Shenjincao (Herba Lycopodii Japonici), Weilingxian (Radix et Rhizoma Clematidis Chinensis), Chuanwu (Radix Aconiti), Haitongpi (Cortex Erythrinae Variegatae), Ruxiang (Olibanum), Danggui (Radix Angelicae Sinensis), Caowu (Radix Aconiti Kusnezoffii), Moyao (Myrrha), and Aiye (Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. (C) 2013 JTCM. All rights reserved.

引用

页码：686 / 691

页数：6

共 10 条

[1]

Chen JX, 2008, THESIS GRADUATE U CH, P7

[2] THE EFFECTS OF SPECIFIC MEDICAL CONDITIONS ON THE FUNCTIONAL LIMITATIONS OF ELDERS IN THE FRAMINGHAM-STUDY [J].

GUCCIONE, AA ;

FELSON, DT ;

ANDERSON, JJ ;

ANTHONY, JM ;

ZHANG, YQ ;

WILSON, PWF ;

KELLYHAYES, M ;

WOLF, PA ;

KREGER, BE ;

KANNEL, WB .

AMERICAN JOURNAL OF PUBLIC HEALTH, 1994, 84 (03) :351-358

[3]

Liu Xiao-he, 2004, Proceedings of the CSEE, V24, P30

[4]

Liu XQ, 2005, JIANGSU ZHONG YI YAO, V26, P63

[5]

Ou Zhi-Xue, 2008, Zhongguo Zhong Xi Yi Jie He Za Zhi, V28, P925

[6]

Tang SH, 2009, SHI JIE KE XUE JI SH, V11, P225

[7] Research on Component Law of Chinese Patent Medicine for Anti-influenza and Development of New Recipes for Anti-influenza by Unsupervised Data Mining Methods [J].

Tang Shi-huan ;

Chen Jian-xin ;

Li Geng ;

Wu Hong-wei ;

Chen Chang ;

Zhang Na ;

Gao Na ;

Yang Hong-jun ;

Huang Lu-qi .

JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2010, 30 (04) :288-293

[8]

Woolf AD, 2003, B WORLD HEALTH ORGAN, V81, P646

[9]

Yang HJ, 2005, ZHONG GUO ZHONG YI J, V11, P706

[10] NEW DRUG R&D OF TRADITIONAL CHINESE MEDICINE: ROLE OF DATA MINING APPROACHES [J].

Yang, Hongjun ;

Chen, Jianxin ;

Tang, Shihuan ;

Li, Zhenkun ;

Zhen, Yisong ;

Huang, Luqi ;

Yi, Jianqiang .

JOURNAL OF BIOLOGICAL SYSTEMS, 2009, 17 (03) :329-347

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