Gut Immunity: A NOD to the Commensals

被引:10
作者
Chen, Grace Y. [1 ,2 ]
Nunez, Gabriel [2 ,3 ]
机构
[1] Univ Michigan, Sch Med, Dept Internal Med, Div Hematol & Oncol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
关键词
RECEPTOR; RECOGNITION; MICROBIOTA; CHEMOKINE; INTESTINE; PROTECTS;
D O I
10.1016/j.cub.2008.12.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gut microbiota play critical roles in intestinal function, but the mechanisms involved remain obscure. Recent studies suggest that commensal bacteria promote immune homeostasis via the innate immune receptor Nod1.
引用
收藏
页码:R171 / R174
页数:4
相关论文
共 20 条
[11]   The Microbes of the Intestine: An Introduction to Their Metabolic and Signaling Capabilities [J].
Hsiao, William W. L. ;
Metz, Christine ;
Singh, Davinder P. ;
Roth, Jesse .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2008, 37 (04) :857-+
[12]   Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo [J].
Masumoto, J ;
Yang, K ;
Varambally, S ;
Hasegawa, M ;
Tomlins, SA ;
Qiu, S ;
Fujimoto, Y ;
Kawasaki, A ;
Foster, SJ ;
Horie, Y ;
Mak, TW ;
Núñez, G ;
Chinnaiyan, AM ;
Fukase, K ;
Inohara, N .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (01) :203-213
[13]   An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system [J].
Mazmanian, SK ;
Liu, CH ;
Tzianabos, AO ;
Kasper, DL .
CELL, 2005, 122 (01) :107-118
[14]   Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells [J].
Park, Jong-Hwan ;
Kim, Yun-Gi ;
Shaw, Michael ;
Kanneganti, Thirumala-Devi ;
Fujimoto, Yukari ;
Fukase, Koichi ;
Inohara, Naohiro ;
Nunez, Gabriel .
JOURNAL OF IMMUNOLOGY, 2007, 179 (01) :514-521
[15]   Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis [J].
Rakoff-Nahoum, S ;
Paglino, J ;
Eslami-Varzaneh, F ;
Edberg, S ;
Medzhitov, R .
CELL, 2004, 118 (02) :229-241
[16]   Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88 [J].
Rakoff-Nahoum, Seth ;
Medzhitov, Ruslan .
SCIENCE, 2007, 317 (5834) :124-127
[17]   Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells [J].
Stappenbeck, TS ;
Hooper, LV ;
Gordon, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15451-15455
[18]   An obesity-associated gut microbiome with increased capacity for energy harvest [J].
Turnbaugh, Peter J. ;
Ley, Ruth E. ;
Mahowald, Michael A. ;
Magrini, Vincent ;
Mardis, Elaine R. ;
Gordon, Jeffrey I. .
NATURE, 2006, 444 (7122) :1027-1031
[19]  
Watanabe T, 2008, J CLIN INVEST, V118, P545, DOI [10.1172/JC133145, 10.1172/JCI33145]
[20]   Innate immunity and intestinal microbiota in the development of Type 1 diabetes [J].
Wen, Li ;
Ley, Ruth E. ;
Volchkov, Pavel Yu. ;
Stranges, Peter B. ;
Avanesyan, Lia ;
Stonebraker, Austin C. ;
Hu, Changyun ;
Wong, F. Susan ;
Szot, Gregory L. ;
Bluestone, Jeffrey A. ;
Gordon, Jeffrey I. ;
Chervonsky, Alexander V. .
NATURE, 2008, 455 (7216) :1109-U10