Gut Immunity: A NOD to the Commensals

被引:10
作者
Chen, Grace Y. [1 ,2 ]
Nunez, Gabriel [2 ,3 ]
机构
[1] Univ Michigan, Sch Med, Dept Internal Med, Div Hematol & Oncol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
关键词
RECEPTOR; RECOGNITION; MICROBIOTA; CHEMOKINE; INTESTINE; PROTECTS;
D O I
10.1016/j.cub.2008.12.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gut microbiota play critical roles in intestinal function, but the mechanisms involved remain obscure. Recent studies suggest that commensal bacteria promote immune homeostasis via the innate immune receptor Nod1.
引用
收藏
页码:R171 / R174
页数:4
相关论文
共 20 条
[1]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[2]   The gut microbiota as an environmental factor that regulates fat storage [J].
Bäckhed, F ;
Ding, H ;
Wang, T ;
Hooper, LV ;
Koh, GY ;
Nagy, A ;
Semenkovich, CF ;
Gordon, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723
[3]   Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor -: Critical regulators of β-defensins during helicobacter pylori infection [J].
Boughan, PK ;
Argent, RH ;
Body-Malapel, M ;
Park, JH ;
Ewings, KE ;
Bowie, AG ;
Ong, SJ ;
Cook, SJ ;
Sorensen, OE ;
Manzo, BA ;
Inohara, N ;
Klein, NJ ;
Nuñez, G ;
Atherton, JC ;
Bajaj-Elliott, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (17) :11637-11648
[4]   Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis [J].
Bouskra, Djahida ;
Brezillon, Christophe ;
Berard, Marion ;
Werts, Catherine ;
Varona, Rosa ;
Boneca, Ivo Gomperts ;
Eberl, Gerard .
NATURE, 2008, 456 (7221) :507-U34
[5]  
Chen G., 2008, ANN REV PATHOL
[6]   The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-induced Tumorigenesis [J].
Chen, Grace Y. ;
Shaw, Michael H. ;
Redondo, Gloria ;
Nunez, Gabriel .
CANCER RESEARCH, 2008, 68 (24) :10060-10067
[7]   Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments [J].
Hasegawa, Mizuho ;
Yang, Kangkang ;
Hashimoto, Masahito ;
Park, Jong-Hwan ;
Kim, Yun-Gi ;
Fujimoto, Yukari ;
Nunez, Gabriel ;
Fukase, Koichi ;
Inohara, Naohiro .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) :29054-29063
[8]   Commensal host-bacterial relationships in the gut [J].
Hooper, LV ;
Gordon, JI .
SCIENCE, 2001, 292 (5519) :1115-1118
[9]   How host-microbial interactions shape the nutrient environment of the mammalian intestine [J].
Hooper, LV ;
Midtvedt, T ;
Gordon, JI .
ANNUAL REVIEW OF NUTRITION, 2002, 22 :283-307
[10]   Molecular analysis of commensal host-microbial relations hips in the intestine [J].
Hooper, LV ;
Wong, MH ;
Thelin, A ;
Hansson, L ;
Falk, PC ;
Gordon, JI .
SCIENCE, 2001, 291 (5505) :881-884