Translating materials design to the clinic

被引：97

作者：

Hubbell, Jeffrey A. ^{[1
,2
,3
]}

Langer, Robert ^{[4
,5
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Sch Engn, CH-1015 Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Sch Basic Sci, CH-1015 Lausanne, Switzerland

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

NATURE MATERIALS | 2013年 / 12卷 / 11期

基金：

欧洲研究理事会;

关键词：

INCORPORATING MICELLAR NANOPARTICLE; LIPID-LIKE MATERIALS; IN-VIVO; POLYMERIC MICELLES; DRUG-DELIVERY; CONJUGATE NANOPARTICLES; SULFIDE NANOPARTICLES; PHASE-I; SIRNA; TUMOR;

D O I：

10.1038/nmat3788

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Many materials-based therapeutic systems have reached the clinic or are in clinical trials. Here we describe materials design principles and the construction of delivery vehicles, as well as their adaptation and evaluation for human use.

引用

页码：963 / 966

页数：4

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