Hedgehog in the Drosophila testis niche: what does it do there?

被引：12
|
作者：
Zhang, Zhao [1 ]
Pan, Chenyu [1 ]
Zhao, Yun [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China
来源：
PROTEIN & CELL | 2013年 / 4卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Drosophila; testis; stem cell; Hedgehog; JAK-STAT; CELL SELF-RENEWAL; SOMATIC STEM-CELLS; CUBITUS-INTERRUPTUS; TRANSCRIPTIONAL ACTIVATOR; REQUIRES PHOSPHORYLATION; PATHWAY ACTIVATION; SIGNALING STRENGTH; IMAGINAL DISKS; PROTEIN-KINASE; DUAL ROLES;
D O I：
10.1007/s13238-013-3040-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cell niche is a specialized microenvironment crucial to self-renewal. The testis in Drosophila contains two different types of stem cells, the germline stem cells and the somatic cyst stem cells that are sustained by their respective niche signals, thus is a good system for studying the interaction between the stem cells and their hosting niche. The JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells, but the roles of several other pathways have emerged recently in a complex signaling network in the testis niche. Reports of independent observations from three research groups have uncovered an important role of Hedgehog (Hh) in the Drosophila testis niche. In this review, we summarize these recent findings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways. We also discuss directions for further investigation.
引用
收藏
页码：650 / 655
页数：6
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