Isoprenoids and Alzheimer's disease: a complex relationship

被引：61
作者：
Cole, SL [1 ]
Vassar, R [1 ]
机构：
[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA
来源：
NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 02期
关键词：
Alzheimer's disease; statins; isoprenoids; cholesterol; APP; metabolism; A beta; neuroinflammation; TaU;
D O I：
10.1016/j.nbd.2005.11.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which Inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under investigation. Whether statins offer benefit for AD will be determined by the outcome of large, placebo-con trolled, randomized clinical trials. However, their use as pharmacological tools has delineated novel roles for isoprenoids in AD. Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：209 / 222
页数：14
相关论文
共 140 条
  • [61] Mutant presenilin (A260V) affects Rab8 in PC12D cell
    Kametani, F
    Usami, M
    Tanaka, K
    Kume, H
    Mori, H
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2004, 44 (05) : 313 - 320
  • [62] Cholesterol is required for surface transport of influenza virus hemagglutinin
    Keller, P
    Simons, K
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 140 (06) : 1357 - 1367
  • [63] Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    Kivipelto, M
    Helkala, EL
    Laakso, MP
    Hänninen, T
    Hallikainen, M
    Alhainen, K
    Iivonen, S
    Mannermaa, A
    Tuomilehto, J
    Nissinen, A
    Soininen, H
    [J]. ANNALS OF INTERNAL MEDICINE, 2002, 137 (03) : 149 - 155
  • [64] Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer's disease
    Klein, WL
    Stine, WB
    Teplow, DB
    [J]. NEUROBIOLOGY OF AGING, 2004, 25 (05) : 569 - 580
  • [65] Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
    Kojro, E
    Gimpl, G
    Lammich, S
    März, W
    Fahrenholz, F
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) : 5815 - 5820
  • [66] Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease
    Kölsch, H
    Ptok, U
    Mohamed, I
    Schmitz, S
    Rao, ML
    Maier, W
    Heun, R
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 121B (01): : 128 - 130
  • [67] Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
    Kukar, T
    Murphy, MP
    Eriksen, JL
    Sagi, SA
    Weggen, S
    Smith, TE
    Ladd, T
    Khan, MA
    Kache, R
    Beard, J
    Dodson, M
    Merit, S
    Ozols, VV
    Anastasiadis, PZ
    Das, P
    Fauq, A
    Koo, EH
    Golde, TE
    [J]. NATURE MEDICINE, 2005, 11 (05) : 545 - 550
  • [68] Statins downregulate myeloperoxidase gene expression in macrophages
    Kumar, AP
    Reynolds, WF
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (02) : 442 - 451
  • [69] Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects
    Kumar, B
    Andreatta, C
    Koustas, WT
    Cole, WC
    Edwards-Prasad, J
    Prasad, KN
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 68 (05) : 627 - 635
  • [70] Kuo YM, 1996, J BIOL CHEM, V271, P4077
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