Isoprenoids and Alzheimer's disease: a complex relationship

被引：61
作者：
Cole, SL [1 ]
Vassar, R [1 ]
机构：
[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA
来源：
NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 02期
关键词：
Alzheimer's disease; statins; isoprenoids; cholesterol; APP; metabolism; A beta; neuroinflammation; TaU;
D O I：
10.1016/j.nbd.2005.11.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which Inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under investigation. Whether statins offer benefit for AD will be determined by the outcome of large, placebo-con trolled, randomized clinical trials. However, their use as pharmacological tools has delineated novel roles for isoprenoids in AD. Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：209 / 222
页数：14
相关论文
共 140 条
  • [1] Neuronal membrane cholesterol loss enhances amyloid pepticle generation
    Abad-Rodriguez, J
    Ledesma, MD
    Craessaerts, K
    Perga, S
    Medina, M
    Delacourte, A
    Dingwall, C
    De Strooper, B
    Dotti, CG
    [J]. JOURNAL OF CELL BIOLOGY, 2004, 167 (05) : 953 - 960
  • [2] INTRACELLULAR-LOCALIZATION OF THE P21(RHO) PROTEINS
    ADAMSON, P
    PATERSON, HF
    HALL, A
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 119 (03) : 617 - 627
  • [3] ADAMSON P, 1992, J BIOL CHEM, V267, P20033
  • [4] Alsop DC, 2000, ANN NEUROL, V47, P93, DOI 10.1002/1531-8249(200001)47:1<93::AID-ANA15>3.3.CO
  • [5] 2-#
  • [6] Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists - The Cache County Study
    Anthony, JC
    Breitner, JCS
    Zandi, PP
    Meyer, MR
    Jurasova, I
    Norton, MC
    Stone, SV
    [J]. NEUROLOGY, 2000, 54 (11) : 2066 - 2071
  • [7] LRP and senile plaques in Alzheimer's disease:: colocalization with apolipoprotein E and with activated astrocytes
    Arélin, K
    Kinoshita, A
    Whelan, CM
    Irizarry, MC
    Rebeck, GW
    Strickland, DK
    Hyman, BT
    [J]. MOLECULAR BRAIN RESEARCH, 2002, 104 (01): : 38 - 46
  • [8] Neurodegeneration and plasticity
    Arendt, T
    [J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2004, 22 (07) : 507 - 514
  • [9] Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease
    Bales, KR
    Verina, T
    Cummins, DJ
    Du, YS
    Dodel, TC
    Saura, J
    Fishman, CE
    DeLong, CA
    Piccardo, P
    Petegnief, V
    Ghetti, B
    Paul, SM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 15233 - 15238
  • [10] The blood-brain barrier: an overview - Structure, regulation, and clinical implications
    Ballabh, P
    Braun, A
    Nedergaard, M
    [J]. NEUROBIOLOGY OF DISEASE, 2004, 16 (01) : 1 - 13
12345678910