H-NS and RpoS regulate emergence of Lac Ara(+) mutants of Escherichia coli MCS2

被引:41
|
作者
GomezGomez, JM [1 ]
Blazquez, J [1 ]
Baquero, F [1 ]
Martinez, JL [1 ]
机构
[1] CSIC,BANCO CELULAS,CTR NACL BIOTECHNOL,E-28049 MADRID,SPAIN
关键词
D O I
10.1128/jb.179.14.4620-4622.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Two master growth-phase regulatory proteins, H-NS and sigma(S), are involved in the formation of araB-lacZ fusion clones of Escherichia coli MCS2. The stationary-phase sigma factor RpoS is strictly required for the appearance of such mutants, whereas the histone-like protein H-NS represses their emergence. Our results support the idea that genetic changes leading do adaptive mutation in this model system are regulated by physiological signal transduction networks.
引用
收藏
页码:4620 / 4622
页数:3
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