Two master growth-phase regulatory proteins, H-NS and sigma(S), are involved in the formation of araB-lacZ fusion clones of Escherichia coli MCS2. The stationary-phase sigma factor RpoS is strictly required for the appearance of such mutants, whereas the histone-like protein H-NS represses their emergence. Our results support the idea that genetic changes leading do adaptive mutation in this model system are regulated by physiological signal transduction networks.
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Korea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South KoreaKorea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South Korea
Oh, TJ
Jung, IL
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Korea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South KoreaKorea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South Korea
Jung, IL
Kim, IG
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Korea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South KoreaKorea Atom Energy Res Inst, Environm Radiat Res Grp, Dept Radiat Biol, Taejon 305600, South Korea