New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases

被引：9
作者：
Knowles, Charles H. [1 ]
Martin, Joanne E. [1 ]
机构：
[1] Barts & London Queen Marys Sch Med & Dent, Ctr Acad Surg & Pathol, Inst Cellular & Mol Sci, London, England
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 02期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Enteric myopathy; Enteric neuropathy; Interstitial cells of Cajal; Intestinal pseudo-obstruction; Visceral pain; FULL-THICKNESS BIOPSY; INTERSTITIAL-CELLS; INTESTINAL PSEUDOOBSTRUCTION; TYROSINE KINASE; AUTOANTIBODIES; NEOPLASIA; CAJAL; CONSTIPATION; NEUROPATHY; MUTATIONS;
D O I：
10.3748/wjg.15.192
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastrointestinal neuromuscular diseases are a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular (including interstitial cell of Cajal) dysfunction. Common to most of these diseases are symptoms of impaired motor activity which manifest as slowed or obstructed transit with or without evidence of transient or persistent radiological visceral dilatation. A variety of histopathological techniques and allied investigations are being increasingly applied to tissue biopsies from such patients. This review outlines some of the more recent advances in this field, particularly in the most contentious area of small bowel disease manifesting as intestinal pseudo-obstruction. (c) 2009 The WJG Press and Baishideng. All rights reserved
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页码：192 / 197
页数：6
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