Organophosphate hydrolase - an enzyme catalyzing degradation of phosphorus-containing toxins and pesticides

被引：52

作者：

Efremenko, EN ^{[1
]}

Sergeeva, VS ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2001年 / 50卷 / 10期

关键词：

organophosphate hydrolase; mechanism of enzymatic catalysis; organophosphorus neurotoxins; amines; substrate specificity; inhibitors;

D O I：

10.1023/A:1014377912147

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The available investigations on the structure and properties of the enzyme organophosphate hydrolase exhibiting catalytic activity with respect to orthophosphates are reviewed. Recent data on the mechanism of enzymatic hydrolysis of paraoxon are surveyed. The role of two metal ions involved in the enzyme active site is considered. The substrate specificity and the influence of various inhibitors on the kinetic characteristics of the enzyme are discussed.

引用

页码：1826 / 1832

页数：7

共 2 条

[1] Organophosphate hydrolase — an enzyme catalyzing degradation of phosphorus-containing toxins and pesticides
E. N. Efremenko
V. S. Sergeeva
Russian Chemical Bulletin, 2001, 50 : 1826 - 1832
[2] PHOSPHORUS-CONTAINING PEPTIDES AS MIXED INHIBITORS OF ENDOPEPTIDASE-3.4.24.15 AND ENDOPEPTIDASE-3.4.24.16 - EFFECT ON NEUROTENSIN DEGRADATION IN-VITRO AND IN-VIVO
VINCENT, B
DIVE, V
YIOTAKIS, A
SMADJA, C
MALDONADO, R
VINCENT, JP
CHECLER, F
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (06) : 1053 - 1063

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