Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation

被引：63

作者：

Cao, Yanan ^{[1
,2
]}

Xue, Ying ^{[1
,2
]}

Xue, Lu ^{[1
,2
]}

Jiang, Xiuli ^{[1
,2
]}

Wang, Xiaolin ^{[1
,2
]}

Zhang, Zhijian ^{[1
,2
]}

Yang, Jian ^{[1
,2
]}

Lu, Jieli ^{[1
,2
]}

Zhang, Changxian ^{[5
]}

Wang, Weiqing ^{[1
,2
]}

Ning, Guang ^{[1
,2
,3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Dept Endocrinol & Metab, Rui Jin Hosp,Sch Med, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Shanghai Inst Endocrinol & Metab, Shanghai 200025, Peoples R China

[3] Chinese Acad Sci, Lab Endocrinol & Metab, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[5] Univ Lyon 1, Lab Genet Mol Signalisat & Canc, CNRS, Fac Med,Ctr Leon Berard,UMR5201, F-69365 Lyon, France

来源：

JOURNAL OF HEPATOLOGY | 2013年 / 59卷 / 06期

关键词：

Menin; SIRT1; Aging; Liver steatosis; Histone deacetylation; INSULIN-RESISTANCE; TUMOR-SUPPRESSOR; CALORIE RESTRICTION; MICE; RECEPTOR; DISEASE; METABOLISM; GLUCOSE; PROTEIN; PROLIFERATION;

D O I：

10.1016/j.jhep.2013.07.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: The development and progression of nonalcoholic fatty liver disease are associated with aging, obesity, and type 2 diabetes. Understanding the precise regulatory networks of this process will contribute to novel therapeutic strategies. Methods: Hepatocyte-specific Men1 knockout mice were generated using Cre/loxP technology. Lipid and glucose metabolic phenotypes and mechanisms were investigated in aging and high-fat diet fed mice. Results: The expression of menin, encoded by multiple endocrine neoplasia 1 (Men1) gene, is reduced in the liver of aging mice. Hepatocyte-specific deletion of Men1 induces liver steatosis in aging mice. Menin deficiency promotes high-fat diet-induced liver steatosis in mice. Menin recruits SIRT1 to control hepatic CD36 expression and triglyceride accumulation through histone deacetylation. Conclusions: Our work reveals that the adaptor protein menin is critical for the progression of hepatic steatosis during aging and metabolic imbalance. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：1299 / 1306

页数：8

共 49 条

[1] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[2] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[3] The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans [J].

Benhamed, Fadila ;

Denechaud, Pierre-Damien ;

Lemoine, Maud ;

Robichon, Celine ;

Moldes, Marthe ;

Bertrand-Michel, Justine ;

Ratziu, Vlad ;

Serfaty, Lawrence ;

Housset, Chantal ;

Capeau, Jacqueline ;

Girard, Jean ;

Guillou, Herve ;

Postic, Catherine .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (06) :2176-2194

[4]

Bertolino P, 2003, CANCER RES, V63, P4836

[5] PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans [J].

Bezy, Olivier ;

Tran, Thien T. ;

Pihlajamaki, Jussi ;

Suzuki, Ryo ;

Emanuelli, Brice ;

Winnay, Jonathan ;

Mori, Marcelo A. ;

Haas, Joel ;

Biddinger, Sudha B. ;

Leitges, Michael ;

Goldfine, Allison B. ;

Patti, Mary Elizabeth ;

King, George L. ;

Kahn, C. Ronald .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2504-2517

[6] Calorie restriction, SIRT1 and metabolism: Understanding longevity [J].

Bordone, L ;

Guarente, L .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :298-305

[7] Nuclear-Cytoplasmic Shuttling of Menin Regulates Nuclear Translocation of β-Catenin [J].

Cao, Yanan ;

Liu, Ruixin ;

Jiang, Xiuli ;

Lu, Jieli ;

Jiang, Jingjing ;

Zhang, Changxian ;

Li, Xiaoying ;

Ning, Guang .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (20) :5477-5487

[8] Tissue-specific regulation of SIRT1 by calorie restriction [J].

Chen, Danica ;

Bruno, Joanne ;

Easlon, Erin ;

Lin, Su-Ju ;

Cheng, Hwei-Ling ;

Alt, Frederick W. ;

Guarente, Leonard .

GENES & DEVELOPMENT, 2008, 22 (13) :1753-1757

[9] Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha [J].

Cheng, Peng ;

Yang, Sheng Sheng ;

Hua, Xian Gui ;

Zhou, Xu Yu ;

Zhang, Yi Jie ;

Jin, Gang ;

Zhou, Ying Qi .

FEBS LETTERS, 2011, 585 (21) :3403-3408

[10] Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice [J].

Choi, JH ;

Nam, KH ;

Kim, J ;

Baek, MW ;

Park, JE ;

Park, HY ;

Kwon, HJ ;

Kwon, OS ;

Kim, DY ;

Oh, GT .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (11) :2404-2409

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