Amino Acid Profiles of Serum and Urine in Search for Prostate Cancer Biomarkers: a Pilot Study

被引:90
作者
Derezinski, Pawel [1 ]
Klupczynska, Agnieszka [1 ]
Sawicki, Wojciech [2 ]
Palka, Jerzy A. [3 ]
Kokot, Zenon J. [1 ]
机构
[1] Poznan Univ Med Sci, Dept Inorgan & Analyt Chem, 6 Grunwaldzka St, PL-60780 Poznan, Poland
[2] Holy Family Hosp, Ward Urol, 18 Jarochowskiego St, PL-60235 Bialystok, Poland
[3] Med Univ Bialystok, Dept Med Chem, 2d Mickiewicza St, PL-15222 Bialystok, Poland
关键词
prostate cancer; amino acids; metabolomics; serum; urine; RECTAL EXAMINATION FAILS; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; NITRIC-OXIDE; METABOLOMICS; SARCOSINE; DERIVATIZATION; IDENTIFICATION; MICROEXTRACTION; QUANTIFICATION;
D O I
10.7150/ijms.15783
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is a great interest in searching for diagnostic biomarkers in prostate cancer patients. The aim of the pilot study was to evaluate free amino acid profiles in their serum and urine. The presented paper shows the first comprehensive analysis of a wide panel of amino acids in two different physiological fluids obtained from the same groups of prostate cancer patients (n = 49) and healthy men (n = 40). The potential of free amino acids, both proteinogenic and non-proteinogenic, as prostate cancer biomarkers and their utility in classification of study participants have been assessed. Several metabolites, which deserve special attention in the further metabolomic investigations on searching for prostate cancer markers, were indicated. Moreover, free amino acid profiles enabled to classify samples to one of the studied groups with high sensitivity and specificity. The presented research provides a strong evidence that ethanolamine, arginine and branched-chain amino acids metabolic pathways can be a valuable source of markers for prostate cancer. The altered concentrations of the above-mentioned metabolites suggest their role in pathogenesis of prostate cancer and they should be further evaluated as clinically useful markers of prostate cancer.
引用
收藏
页码:1 / 12
页数:12
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