pH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

被引：92
|
作者：
Kim, MS
Hwang, SJ
Han, JK
Choi, EK
Park, HJ
Kim, JS
Lee, DS [1 ]
机构：
[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea
[2] Univ Ulsan, Dept Radiat Oncol, Ulsan 680749, South Korea
[3] Inha Univ, Coll Med, Dept Microbiol, Inchon 402751, South Korea
[4] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2006年 / 27卷 / 06期
关键词：
block copolymers; micelles; pH-sensitive polymer; pKb value; polymeric rnicelle; poly(beta-amino esters);
D O I：
10.1002/marc.200500769
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and hydrophobic but pH-sensitive poly(beta-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(beta-amino ester).
引用
收藏
页码：447 / 451
页数：5
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