pH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

被引：92

作者：

Kim, MS

Hwang, SJ

Han, JK

Choi, EK

Park, HJ

Kim, JS

Lee, DS ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea

[2] Univ Ulsan, Dept Radiat Oncol, Ulsan 680749, South Korea

[3] Inha Univ, Coll Med, Dept Microbiol, Inchon 402751, South Korea

[4] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2006年 / 27卷 / 06期

关键词：

block copolymers; micelles; pH-sensitive polymer; pKb value; polymeric rnicelle; poly(beta-amino esters);

D O I：

10.1002/marc.200500769

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and hydrophobic but pH-sensitive poly(beta-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(beta-amino ester).

引用

页码：447 / 451

页数：5

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