pH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

被引：92
|
作者：
Kim, MS
Hwang, SJ
Han, JK
Choi, EK
Park, HJ
Kim, JS
Lee, DS [1 ]
机构：
[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea
[2] Univ Ulsan, Dept Radiat Oncol, Ulsan 680749, South Korea
[3] Inha Univ, Coll Med, Dept Microbiol, Inchon 402751, South Korea
[4] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2006年 / 27卷 / 06期
关键词：
block copolymers; micelles; pH-sensitive polymer; pKb value; polymeric rnicelle; poly(beta-amino esters);
D O I：
10.1002/marc.200500769
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and hydrophobic but pH-sensitive poly(beta-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(beta-amino ester).
引用
收藏
页码：447 / 451
页数：5
相关论文
共 50 条
  • [21] Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer
    Zhao, Changwen
    He, Pan
    Xiao, Chunsheng
    Gao, Xiaoye
    Zhuang, Xiuli
    Chen, Xuesi
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2011, 359 (02) : 436 - 442
  • [22] pH-responsive micelles and vesicles formed from a water-soluble schizophrenic diblock copolymer
    Enomoto, Ryusuke
    Khimani, Mehul
    Bahadur, Pratap
    Yusa, Shin-ichi
    JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2014, 45 (06) : 3117 - 3123
  • [23] Temperature- and pH-Responsive Micelles with Collapsible Poly(N-isopropylacrylamide) Headgroups
    FitzGerald, Paul A.
    Gupta, Sushen
    Wood, Kathleen
    Perrier, Sebastien
    Warr, Gregory G.
    LANGMUIR, 2014, 30 (27) : 7986 - 7992
  • [24] pH-responsive amphiphilic block copolymer prodrug conjugated near infrared fluorescence probe
    Xing, Tao
    Yan, Lifeng
    RSC ADVANCES, 2014, 4 (54): : 28186 - 28194
  • [25] pH-responsive dithiomaleimide-amphiphilic block copolymer for drug delivery and cellular imaging
    Bai, Ting
    Shao, Dongyan
    Chen, Jianxin
    Li, Yifan
    Xu, Ben Bin
    Kong, Jie
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2019, 552 : 439 - 447
  • [26] pH-responsive nanoparticles based on optimized synthetic amphiphilic poly(β-amino esters) for doxorubicin delivery
    Gao, Feng
    Wang, Qiang
    Yang, Xiaochun
    COLLOID AND POLYMER SCIENCE, 2020, 298 (03) : 303 - 312
  • [27] pH-sensitive and bioadhesive poly(β-amino ester)-poly(ethylene glycol)-poly(β-amino ester) triblock copolymer hydrogels with potential for drug delivery in oral mucosal surfaces
    Nguyen, Minh Khanh
    Huynh, Cong Truc
    Lee, Doo Sung
    POLYMER, 2009, 50 (22) : 5205 - 5210
  • [28] Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery
    Zhang, Can Yang
    Yang, You Qiang
    Huang, Tu Xiong
    Zhao, Bin
    Guo, Xin Dong
    Wang, Ju Fang
    Zhang, Li Juan
    BIOMATERIALS, 2012, 33 (26) : 6273 - 6283
  • [29] Block copolymer-templated mineralization for pH-responsive robust nanocarriers of 5-fluorouracil
    Choi, Gi Hyun
    Min, Kyung Hyun
    Lee, Sang Cheon
    MACROMOLECULAR RESEARCH, 2014, 22 (03) : 329 - 336
  • [30] Photo- and pH-Responsive Polycarbonate Block Copolymer Prodrug Nanomicelles for Controlled Release of Doxorubicin
    Kalva, Nagendra
    Uthaman, Saji
    Augustine, Rimesh
    Jeon, Su Hyeon
    Huh, Kang Moo
    Park, In-Kyu
    Kim, Il
    MACROMOLECULAR BIOSCIENCE, 2020, 20 (08)
12345