Role of Transcriptional Corepressor CtBP1 in Prostate Cancer Progression

被引：63

作者：

Wang, Rui

Asangani, Irfan A.

Chakravarthi, Balabhadrapatruni V. S. K.

Ateeq, Bushra

Lonigro, Robert J. ^{[2
]}

Cao, Qi

Mani, Ram-Shankar

Camacho, Daniel F. ^{[3
]}

McGregor, Natalie ^{[3
]}

Schumann, Taibriana E. W. ^{[3
]}

Jing, Xiaojun

Menawat, Radhika ^{[4
]}

Tomlins, Scott A.

Zheng, Heng

Otte, Arie P. ^{[5
]}

Mehra, Rohit

Siddiqui, Javed

Dhanasekaran, Saravana M.

Nyati, Mukesh K. ^{[2
,4
]}

Pienta, Kenneth J. ^{[6
]}

Palanisamy, Nallasivam ^{[2
]}

Kunju, Lakshmi P.

Rubin, Mark A. ^{[7
,8
]}

Chinnaiyan, Arul M. ^{[2
,9
]}

Varambally, Sooryanarayana ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[5] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[6] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[7] Weill Cornell Canc Ctr, Dept Pathol, New York, NY USA

[8] Weill Cornell Canc Ctr, Dept Lab Med, New York, NY USA

[9] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

NEOPLASIA | 2012年 / 14卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TERMINAL-BINDING-PROTEIN; ADENOVIRUS E1A; BREAST-CANCER; CELL-SURVIVAL; E-CADHERIN; METASTASIS; GENE; RECRUITMENT; EXPRESSION; REPRESSOR;

D O I：

10.1593/neo.121192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transcriptional repressors and corepressors play a critical role in cellular homeostasis and are frequently altered in cancer. C-terminal binding protein 1 (CtBP1), a transcriptional corepressor that regulates the expression of tumor suppressors and genes involved in cell death, is known to play a role in multiple cancers. In this study, we observed the overexpression and mislocalization of CtBP1 in metastatic prostate cancer and demonstrated the functional significance of CtBP1 in prostate cancer progression. Transient and stable knockdown of CtBP1 in prostate cancer cells inhibited their proliferation and invasion. Expression profiling studies of prostate cancer cell lines revealed that multiple tumor suppressor genes are repressed by CtBP1. Furthermore, our studies indicate a role for CtBP1 in conferring radiation resistance to prostate cancer cell lines. In vivo studies using chicken chorioallantoic membrane assay, xenograft studies, and murine metastasis models suggested a role for CtBP1 in prostate tumor growth and metastasis. Taken together, our studies demonstrated that dysregulated expression of CtBP1 plays an important role in prostate cancer progression and may serve as a viable therapeutic target. Neoplasia (2012) 14, 905-914

引用

页码：905 / U46

页数：14

共 36 条

[1] Role of Cell Cycle in Epidermal Growth Factor Receptor Inhibitor-Mediated Radiosensitization [J].