Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population

被引：13

作者：

Egawa, Jun ^{[1
,2
]}

Nunokawa, Ayako ^{[1
,3
]}

Shibuya, Masako ^{[1
,4
]}

Watanabe, Yuichiro ^{[1
,5
]}

Kaneko, Naoshi ^{[1
,6
]}

Igeta, Hirofumi ^{[1
]}

Someya, Toshiyuki ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Niigata 9518510, Japan

[2] Saigata Natl Hosp, Dept Psychiat, Natl Hosp Org, Niigata, Japan

[3] Niigata Psychiat Ctr, Niigata, Japan

[4] Headquarters Hlth Adm, Hlth Adm Ctr, Niigata, Japan

[5] Niigata Univ, Div Med Educ, Comprehens Med Educ Ctr, Sch Med,Fac Med, Niigata 9518510, Japan

[6] Oojima Hosp, Niigata, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2013年 / 67卷 / 04期

关键词：

MIR137; resequencing; schizophrenia; single nucleotide variation; variable number of tandem repeats; GENE;

D O I：

10.1111/pcn.12047

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia.

引用

页码：277 / 279

页数：3

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