Biology of TGF-beta in knockout and transgenic mouse models

被引：145
作者：
Bottinger, EP [1 ]
Letterio, JJ [1 ]
Roberts, AB [1 ]
机构：
[1] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892
来源：
KIDNEY INTERNATIONAL | 1997年 / 51卷 / 05期
关键词：
D O I：
10.1038/ki.1997.185
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
This paper reviews the basic biology and biochemistry of the TGF-P isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or recepotr/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.
引用
收藏
页码：1355 / 1360
页数：6
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