Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

被引:43
作者
Caini, Saverio [1 ]
Bellerba, Federica [2 ]
Corso, Federica [2 ]
Diaz-Basabe, Angelica [2 ]
Natoli, Gioacchino [2 ]
Paget, John [3 ]
Facciotti, Federica [2 ]
De Angelis, Simone Pietro [2 ]
Raimondi, Sara [2 ]
Palli, Domenico [1 ]
Mazzarella, Luca [2 ]
Pelicci, Pier Giuseppe [2 ,4 ]
Vineis, Paolo [5 ]
Gandini, Sara [2 ]
机构
[1] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Lifestyle Epidemiol Unit, Florence, Italy
[2] IRCCS, European Inst Oncol IEO, Dept Expt Oncol, Milan, Italy
[3] Netherlands Inst Hlth Serv Res NIVEL, Utrecht, Netherlands
[4] Univ Milan, Dept Hematol & Oncol, Milan, Italy
[5] Imperial Coll, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England
关键词
D O I
10.2807/1560-7917.ES.2020.25.23.2000980
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with <= 5% of seroconverted individuals, unless the assays have perfect (i.e. log%) specificity, the positive predictive value would be <= 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
引用
收藏
页码:9 / 13
页数:5
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