Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

被引：43

作者：

Caini, Saverio ^{[1
]}

Bellerba, Federica ^{[2
]}

Corso, Federica ^{[2
]}

Diaz-Basabe, Angelica ^{[2
]}

Natoli, Gioacchino ^{[2
]}

Paget, John ^{[3
]}

Facciotti, Federica ^{[2
]}

De Angelis, Simone Pietro ^{[2
]}

Raimondi, Sara ^{[2
]}

Palli, Domenico ^{[1
]}

Mazzarella, Luca ^{[2
]}

Pelicci, Pier Giuseppe ^{[2
,4
]}

Vineis, Paolo ^{[5
]}

Gandini, Sara ^{[2
]}

机构：

[1] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Lifestyle Epidemiol Unit, Florence, Italy

[2] IRCCS, European Inst Oncol IEO, Dept Expt Oncol, Milan, Italy

[3] Netherlands Inst Hlth Serv Res NIVEL, Utrecht, Netherlands

[4] Univ Milan, Dept Hematol & Oncol, Milan, Italy

[5] Imperial Coll, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England

来源：

EUROSURVEILLANCE | 2020年 / 25卷 / 23期

关键词：

D O I：

10.2807/1560-7917.ES.2020.25.23.2000980

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with <= 5% of seroconverted individuals, unless the assays have perfect (i.e. log%) specificity, the positive predictive value would be <= 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.

引用

页码：9 / 13

页数：5

共 14 条

[1]

Adams ER, 2020, EVALUATION ANTIBODY

[2]

[Anonymous], IMM PASS CONT COVID

[3] Effect of surface treatment on electrical properties of GaN metal-insulator-semiconductor devices with Al2O3 gate dielectric [J].

Cai, Yutao ;

Liu, Wen ;

Cui, Miao ;

Sun, Ruize ;

Liang, Yung C. ;

Wen, Huiqing ;

Yang, Li ;

Supardan, Siti N. ;

Mitrovic, Ivona Z. ;

Taylor, Stephen ;

Chalker, Paul R. ;

Zhao, Cezhou .

JAPANESE JOURNAL OF APPLIED PHYSICS, 2020, 59 (04)

[4]

Creative Diagnostics (CD), SARS COV 2 IGG ELISA

[5] Covid-19: identifying and isolating asymptomatic people helped eliminate virus in Italian village [J].

Day, Michael .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 368 :m1165

[6]

Epitope Diagnostics Inc. (EDI), NOV COR COVID 19 IGG

[7] The diagnostic odds ratio: a single indicator of test performance [J].

Glas, AS ;

Lijmer, JG ;

Prins, MH ;

Bonsel, GJ ;

Bossuyt, PMM .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (11) :1129-1135

[8]

Immunodiagnostic Products VITROS, ANT SARS COV 2 TOT R

[9]

Lassauniere R, 2020, EVALUATION 9 COMMERC

[10]

Lin D, 2020, EVALUATIONS SEROLOGI

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