Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

被引：11

作者：

Colon, Aude ^{[1
]}

Hoffman, Thomas J. ^{[1
,2
]}

Gebauer, Julian ^{[1
]}

Dash, Jyotirmayee ^{[1
]}

Rigby, James H. ^{[2
]}

Arseniyadis, Stellios ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] ESPCI ParisTech, CNRS, Chim Organ Lab, F-75231 Paris 05, France

[2] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 85期

关键词：

BITHIAZOLE-TYPE ANTIBIOTICS; ALPHA-CHLORINATION; CYSTOTHIAZOLE-A; MELITHIAZOLS;

D O I：

10.1039/c2cc35721f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

引用

页码：10508 / 10510

页数：3

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