Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

被引：59

作者：

Tominari, Tsukasa

Hirata, Michiko ^{[1
]}

Matsumoto, Chiho ^{[1
]}

Inada, Masaki ^{[1
]}

Miyaura, Chisato ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Dept Biotechnol & Life Sci, Koganei, Tokyo 1848588, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2012年 / 119卷 / 04期

关键词：

polymethoxy flavonoid; inflammatory bone resorption; periodontal disease; PROSTAGLANDIN-E SYNTHESIS; ESTROGEN DEFICIENCY; KAPPA-B; CITRUS; RESORPTION; MICE; CYCLOOXYGENASE-2; OSTEOBLASTS; CELLS; E-2;

D O I：

10.1254/jphs.11188SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NF kappa B ligand-induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss.

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收藏

页码：390 / 394

页数：5

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