A General Method for Palladium-Catalyzed Direct Carbonylation of Indole with Alcohol and Phenol

被引：65

作者：

Lang, Rui ^{[1
,3
]}

Shi, Lijun ^{[1
]}

Li, Dengfeng ^{[1
]}

Xia, Chungu ^{[1
]}

Li, Fuwei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215123, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE CARBONYLATION; MULTICOMPONENT SYNTHESIS; COUPLING REACTIONS; ARYL HALIDES; ESTERS; CARBOXYLATION; BONDS; ALKOXYCARBONYLATION; FUNCTIONALIZATION; IMINES;

D O I：

10.1021/ol3017726

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel strategy involving a first oxidative iodination and subsequent Pd-0-catalyzed carbonylation to yield indole-3-carboxylate has been developed. It showed perfect generality to indole, alcohol, and phenol. The current methodology could also be conveniently applied to the synthesis of biologically active tropisetron from simple indole and tropine.

引用

页码：4130 / 4133

页数：4

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