Addition of Zn to the ternary Mg-Ca-Sr alloys significantly improves their antibacterial properties

被引:84
作者
He, Guanping [1 ,2 ]
Wu, Yuanhao [3 ]
Zhang, Yu [2 ]
Zhu, Ye [4 ]
Liu, Yang [5 ]
Li, Nan [5 ]
Li, Mei [2 ]
Zheng, Guan [1 ,2 ]
He, Baohua [6 ]
Yin, Qingshui [1 ,2 ]
Zheng, Yufeng [3 ,5 ]
Mao, Chuanbin [4 ]
机构
[1] Southern Med Univ, Guangzhou 510515, Guangdong, Peoples R China
[2] Guangzhou Mil Command, Guangzhou Gen Hosp, Guangdong Key Lab Orthoped Technol & Implant, Dept Orthoped, Guangzhou 510010, Guangdong, Peoples R China
[3] Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
[4] Univ Oklahoma, Stephenson Life Sci Res Ctr, Dept Chem & Biochem, Norman, OK 73019 USA
[5] Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
[6] China Meitan Gen Hosp, Dept Orthoped, Beijing 100028, Peoples R China
基金
美国国家卫生研究院; 美国国家科学基金会; 中国国家自然科学基金;
关键词
TITANIUM SURFACES; IN-VITRO; STRONTIUM; MAGNESIUM; METAL; BIOCOMPATIBILITY; STRENGTH; EFFICACY; BINDING; SILICA;
D O I
10.1039/c5tb01319d
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Most of the magnesium (Mg) alloys possess excellent biocompatibility, mechanical properties and biodegradability in orthopedic applications. However, these alloys may suffer from bacterial infections due to their insufficient antibacterial capability. In order to reduce the post-surgical infections, a series of biocompatible Mg-1Ca-0.5Sr-xZn (x = 0, 2, 4, 6) alloys were fabricated with the addition of antibacterial Zn with variable contents and evaluated in terms of their biocompatibility and antibacterial properties. The in vitro corrosion study showed that Mg-1Ca-0.5Sr-6Zn alloys exhibited a higher hydrogen evolution volume after 100 h immersion and resulted in a higher pH value of the immersion solution. Our work indicated that Zn-containing Mg alloys exhibited good biocompatibility with high cell viability. The antibacterial studies reveal that the number of bacteria adhered on all of these Mg alloy samples diminished remarkably compared to the Ti-6Al-4V control group. We also found that the proliferation of the bacteria was inhibited by these Mg alloy extracts. Among the prepared alloys, the Mg-1Ca-0.5Sr-6Zn alloy not only exhibited a strong antibacterial effect, but also promoted the proliferation of MC3T3-E1 osteoblasts, suggesting that it is a promising alloy with both good antibacterial properties and good biocompatibility for use as an orthopedic implant.
引用
收藏
页码:6676 / 6689
页数:14
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