Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets

被引:69
作者
Bontempo, V [1 ]
Sciannimanico, D
Pastorelli, G
Rossi, R
Rosi, F
Corino, C
机构
[1] Univ Milan, Dept Vet Sci & Technol Food Safety, I-20133 Milan, Italy
[2] Univ Milan, Fac Agraria, Ist Zootecn Gen, I-20133 Milan, Italy
关键词
conjugated linoleic acid; immune response; sows; piglets;
D O I
10.1093/jn/134.4.817
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We studied the effects of conjugated linoleic acid (CLA) on metabolic and immunologic variables in lactating sows and piglets. Gestating sows (n = 16) were assigned to 1 of 2 weight- and parity-matched groups supplemented with 0% (C) or 0.5% (T) of a CLA preparation containing 50% CLA isomers. Supplementation started in late pregnancy and continued throughout lactation. At weaning, 80 piglets, half from each group of sows, were assigned to 0% CLA (C) or 0.5% CLA (T). Thus, there were four groups of 20 piglets: C-C, C-T, T-T, and T-C. Body weight and the number of piglets per litter at birth and weaning, and the chemical composition of colostrum did not differ among the groups. CLA affected the fatty acid composition of colostrum fat; palmitoleic and gamma-linolenic acid were significantly lower compared with controls, whereas eicosenoic and eicosatrienoic acids were significantly higher. Feeding CLA increased (P < 0.05) colostrum IgG in sows. Sows fed CLA had higher (P < 0.05) serum leptin, IgG, and lysozyme. Nursing piglets from CLA-fed sows had significantly higher (P < 0.01) serum lysozyme and IgG. Consumption of CLA did not affect postweaning growth. Postweaning piglets fed CLA (T-T, C-T) had a higher IgG titer at 25 d (P < 0.05) and 35 d (P < 0.01) after weaning. Serum lysozyme was also higher at 25 d (P < 0.05) in CLA-fed piglets (T-T, C-T). At 35 d, serum alpha-1 acylglicoprotein was lower (P < 0.05) in piglets fed CLA. Dietary CLA had a positive effect on immunologic variables in lactating sows and piglets.
引用
收藏
页码:817 / 824
页数:8
相关论文
共 54 条
[1]   Leptin [J].
Ahima, RS ;
Flier, JS .
ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437
[2]  
[Anonymous], 1998, NUTR REQ SWIN, V10th
[3]   LIQUID-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS OF CONJUGATED DIENE FATTY-ACIDS IN A PARTIALLY HYDROGENATED FAT [J].
BANNI, S ;
DAY, BW ;
EVANS, RW ;
CORONGIU, FP ;
LOMBARDI, B .
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1994, 71 (12) :1321-1325
[4]   Role of leptin in modulating neuroendocrine function: A metabolic link between the brain-pituitary and adipose tissue [J].
Barb, CR ;
Barrett, JB ;
Kraeling, RR ;
Rampacek, GB .
REPRODUCTION IN DOMESTIC ANIMALS, 1999, 34 (3-4) :111-125
[5]   Biology of leptin in the pig [J].
Barb, CR ;
Hausman, GJ ;
Houseknecht, KL .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2001, 21 (04) :297-317
[6]   Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8+ lymphocytes [J].
Bassaganya-Riera, J ;
Hontecillas, R ;
Zimmerman, DR ;
Wannemuehler, MJ .
JOURNAL OF NUTRITION, 2001, 131 (09) :2370-2377
[7]   Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs [J].
Bee, G .
JOURNAL OF NUTRITION, 2000, 130 (12) :2981-2989
[8]   Dietary conjugated linoleic acids alter adipose tissue and milk lipids of pregnant and lactating sows [J].
Bee, G .
JOURNAL OF NUTRITION, 2000, 130 (09) :2292-2298
[9]   Conjugated linoleic acid modulates hepatic lipid composition in mice [J].
Belury, MA ;
KempaSteczko, A .
LIPIDS, 1997, 32 (02) :199-204
[10]   WEANING PIGS AT AN EARLY AGE DECREASES CELLULAR-IMMUNITY [J].
BLECHA, F ;
POLLMANN, DS ;
NICHOLS, DA .
JOURNAL OF ANIMAL SCIENCE, 1983, 56 (02) :396-400