Chiral Recognition of L-Amino Acids on Liposomes Prepared with L-Phospholipid

被引：81

作者：

Ishigami, Takaaki ^{[1
]}

Suga, Keishi ^{[1
]}

Umakoshi, Hiroshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Div Chem Engn, Toyonaka, Osaka 5608531, Japan

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 38期

基金：

日本学术振兴会;

关键词：

liposomes; chiral recognition; amino acids; adsorption; electrostatic interaction; hydrogen bond; lock-and-key model; TRYPTOPHAN; MEMBRANES; SYSTEM; MODEL; CONFORMATION; ENANTIOMERS; DERIVATIVES; ADSORPTION; MOLECULES; RESONANCE;

D O I：

10.1021/acsami.5b07198

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, we demonstrated that liposomes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) can recognize several L-amino acids, but not their D-enantiomers, by analyzing their adsorptive behavior and using circular dichroism spectroscopy. Changes in liposomal membrane properties, determined based on fluorescent probe analysis and differential scanning calorimetry, were induced by L-amino acid binding. UV resonance Raman spectroscopy analysis suggested that the chiral recognition was mediated by electrostatic, hydrophobic, and hydrogen bond interactions, where the recognition site could therefore be constructed on the DPPC membrane. Our findings clearly indicate the potential function of liposomes in asymmetric recognition.

引用

页码：21065 / 21072

页数：8

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