Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

被引：77

作者：

Jung, Danbi ^{[1
]}

Maiti, Sukhendu ^{[1
]}

Lee, Jae Hong ^{[1
]}

Lee, Joung Hae ^{[2
]}

Kim, Jong Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 136701, South Korea

[2] Korea Res Inst Stand & Sci, Taejon 305600, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

ENDOPLASMIC-RETICULUM; METAL-ION; GLUTATHIONE; FLUORESCENT;

D O I：

10.1039/c3cc49790a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

引用

收藏

页码：3044 / 3047

页数：4

相关论文

共 21 条

[1] Fluorescent and colorimetric probes for detection of thiols [J].

Chen, Xiaoqiang ;

Zhou, Ying ;

Peng, Xiaojun ;

Yoon, Juyoung .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (06) :2120-2135

[2]

Conklin Kenneth A, 2004, Integr Cancer Ther, V3, P294, DOI 10.1177/1534735404270335

[3] A Fluorogenic Probe for the Catalyst-Free Detection of Azide-Tagged Molecules [J].

Friscourt, Frederic ;

Fahrni, Christoph J. ;

Boons, Geert-Jan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (45) :18809-18815

[4] THE STABILITY OF N-ETHYLMALEIMIDE AND ITS REACTION WITH SULFHYDRYL GROUPS [J].

GREGORY, JD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (14) :3922-3923

[5] Synthesis of Light-Emitting Conjugated Polymers for Applications in Electroluminescent Devices [J].

Grimsdale, Andrew C. ;

Chan, Khai Leok ;

Martin, Rainer E. ;

Jokisz, Pawel G. ;

Holmes, Andrew B. .

CHEMICAL REVIEWS, 2009, 109 (03) :897-1091

[6] OXIDIZED REDOX STATE OF GLUTATHIONE IN THE ENDOPLASMIC-RETICULUM [J].

HWANG, C ;

SINSKEY, AJ ;

LODISH, HF .

SCIENCE, 1992, 257 (5076) :1496-1502

[7] Recent progress in luminescent and colorimetric chemosensors for detection of thiols [J].

Jung, Hyo Sung ;

Chen, Xiaoqiang ;

Kim, Jong Seung ;

Yoon, Juyoung .

CHEMICAL SOCIETY REVIEWS, 2013, 42 (14) :6019-6031

[8] Two-photon-induced cycloreversion reaction of coumarin photodimers [J].

Kim, HC ;

Kreiling, S ;

Greiner, A ;

Hampp, N .

CHEMICAL PHYSICS LETTERS, 2003, 372 (5-6) :899-903

[9] BODIPY appended cone-calix[4]arene:: selective fluorescence changes upon Ca2+ binding [J].

Kim, Hyun Jung ;

Kim, Jong Seung .

TETRAHEDRON LETTERS, 2006, 47 (39) :7051-7055

[10] Calixarene-derived fluorescent probes [J].

Kim, Jong Seung ;

Quang, Duong Tuan .

CHEMICAL REVIEWS, 2007, 107 (09) :3780-3799