Thermoresponsive dendrimers based on oligoethylene glycols: Design, synthesis and cytotoxic activity against MCF-7 breast cancer cells

被引：13

作者：

Abdel-Rahman, Mona A. ^{[1
]}

Al-Abd, Ahmed M. ^{[2
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Polymer Lab 122, Assiut 71516, Egypt

[2] Natl Res Ctr, Dept Pharmacol, Div Med, Cairo, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 69卷

关键词：

Cytotoxicity; Tetrabromohydroquinone; Thermoresponsive dendrimers; Synthesis; Water-soluble dendrimers; IN-VITRO; DERIVATIVES; RESISTANCE; POLYMERS; GOLD;

D O I：

10.1016/j.ejmech.2013.09.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone were efficiently synthesized from tetrabromohydroquinone and three different oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement at different temperatures for 0.25 wt% of aqueous solutions from D1, D2 and D3. The cytotoxicity of the prepared dendrimers was tested against MCF-7 breast cancer cells. All tested dendrimers showed considerable results, where D2 dendrimer gave the best result; it showed cytotoxicity against MCF-7 cell line with IC50 of 1.07 mu g/mL and resistant fraction equals 1.97%, the other two dendrimers showed a modest cytotoxic profile. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：848 / 854

页数：7

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