Plasmonic DNA hotspots made from tungsten disulfide nanosheets and gold nanoparticles for ultrasensitive aptamer-based SERS detection of myoglobin

被引：82
作者：
Shorie, Munish [1 ]
Kumar, Vinod [1 ]
Kaur, Harmanjit [1 ]
Singh, Kulvinder [1 ]
Tomer, Vijay K. [1 ]
Sabherwal, Priyanka [1 ]
机构：
[1] Inst Nano Sci & Technol, Mohali 160062, India
来源：
MICROCHIMICA ACTA | 2018年 / 185卷 / 03期
关键词：
Cardiac biomarker; Plasmonic hotspots; SERS aptasensor; SELEX; Nanohybrid; ENHANCED RAMAN-SCATTERING; LABEL-FREE DETECTION; ACUTE MYOCARDIAL-INFARCTION; ELECTROCHEMICAL APTASENSOR; OPTICAL-PROPERTIES; FACILE SYNTHESIS; WHOLE-BLOOD; HOT-SPOTS; WS2; FILM; SPECTROSCOPY;
D O I：
10.1007/s00604-018-2705-x
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A nanohybrid mediated SERS substrate was prepared by in-situ synthesis and assembly of gold nanoparticles (AuNPs) on exfoliated nanosheets of tungsten disulfide (WS2) to form plasmonic hotspots. The nanohybrid surface was functionalized with specific aptamers which imparted high selectivity for the cardiac marker myoglobin (Mb). The fabricated aptasensor was read by SERS using a 532 nm laser and demonstrated significant signal enhancement, and this allowed Mb to be determined in the 10 f.mL(-1) to 0.1 mu g mL(-1) concentration range. The study presents an approach to synergistically exploit the unique chemical and electromagnetic properties of both WS2 and AuNPs for many-fold enhancement of SERS signals.
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页数：8
相关论文
共 43 条
[1]   Electronic and optical properties of MoS2-WS2 multi-layers: First principles study [J].
Ahuja, Ushma ;
Dashora, Alpa ;
Tiwari, Harpal ;
Kothari, Dushyant C. ;
Venugopalan, K. .
COMPUTATIONAL MATERIALS SCIENCE, 2014, 92 :451-456
[2]  
[Anonymous], J CHEM PHYS
[3]   Electrochemistry of Nanostructured Layered Transition-Metal Dichalcogenides [J].
Chia, Xinyi ;
Eng, Alex Yong Sheng ;
Ambrosi, Adriano ;
Tan, Shu Min ;
Pumera, Martin .
CHEMICAL REVIEWS, 2015, 115 (21) :11941-11966
[4]   Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A [J].
Chung, Eunsu ;
Jeon, Jinhyeok ;
Yu, Jimin ;
Lee, Chankil ;
Choo, Jaebum .
BIOSENSORS & BIOELECTRONICS, 2015, 64 :560-565
[5]   Two-Dimensional Nanosheets Produced by Liquid Exfoliation of Layered Materials [J].
Coleman, Jonathan N. ;
Lotya, Mustafa ;
O'Neill, Arlene ;
Bergin, Shane D. ;
King, Paul J. ;
Khan, Umar ;
Young, Karen ;
Gaucher, Alexandre ;
De, Sukanta ;
Smith, Ronan J. ;
Shvets, Igor V. ;
Arora, Sunil K. ;
Stanton, George ;
Kim, Hye-Young ;
Lee, Kangho ;
Kim, Gyu Tae ;
Duesberg, Georg S. ;
Hallam, Toby ;
Boland, John J. ;
Wang, Jing Jing ;
Donegan, John F. ;
Grunlan, Jaime C. ;
Moriarty, Gregory ;
Shmeliov, Aleksey ;
Nicholls, Rebecca J. ;
Perkins, James M. ;
Grieveson, Eleanor M. ;
Theuwissen, Koenraad ;
McComb, David W. ;
Nellist, Peter D. ;
Nicolosi, Valeria .
SCIENCE, 2011, 331 (6017) :568-571
[6]   Building SERS-active heteroassemblies for ultrasensitive Bisphenol A detection [J].
Feng, Jingjing ;
Xu, Liguang ;
Cui, Gang ;
Wu, Xiaoling ;
Ma, Wei ;
Kuang, Hua ;
Xu, Chuanlai .
BIOSENSORS & BIOELECTRONICS, 2016, 81 :138-142
[7]   A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA [J].
Fu, Xiuli ;
Cheng, Ziyi ;
Yu, Jimin ;
Choo, Priscilla ;
Chen, Lingxin ;
Choo, Jaebum .
BIOSENSORS & BIOELECTRONICS, 2016, 78 :530-537
[8]   Highly sensitive detection of human cardiac myoglobin using a reverse sandwich immunoassay with a gold nanoparticle-enhanced surface plasmon resonance biosensor [J].
Gnedenko, Oksana V. ;
Mezentsev, Yury V. ;
Molnar, Andrey A. ;
Lisitsa, Andrey V. ;
Ivanov, Alexis S. ;
Archakov, Alexander I. .
ANALYTICA CHIMICA ACTA, 2013, 759 :105-109
[9]   Plasmons in Strongly Coupled Metallic Nanostructures [J].
Halas, Naomi J. ;
Lal, Surbhi ;
Chang, Wei-Shun ;
Link, Stephan ;
Nordlander, Peter .
CHEMICAL REVIEWS, 2011, 111 (06) :3913-3961
[10]   Use of Single-Layer g-C3N4/Ag Hybrids for Surface-Enhanced Raman Scattering (SERS) [J].
Jiang, Jizhou ;
Zou, Jing ;
Wee, Andrew Thye Shen ;
Zhang, Wenjing .
SCIENTIFIC REPORTS, 2016, 6
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