Two new secondary metabolites from the mangrove endophytic fungus Pleosporales sp. SK7

被引：22

作者：

Wen, Shitong ^{[1
]}

Fan, Weilong ^{[1
]}

Guo, Huixian ^{[1
]}

Huang, Cuiying ^{[1
]}

Yan, Zhangyuan ^{[1
]}

Long, Yuhua ^{[1
]}

机构：

[1] South China Normal Univ, Sch Chem & Environm, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Mangrove fungus metabolism; Pleosporales sp; antibacterial; antioxidant; cytotoxicity; ABSCISIC-ACID; DIPHENYL ETHER; DERIVATIVES;

D O I：

10.1080/14786419.2019.1598993

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds, an abscisic acid-type sesquiterpene (1), and one asterric acid derivative (2), together with three known compounds (3-5) were isolated from mangrove endophytic fungus Pleosporales sp. SK7. The structures of these metabolites were determined by NMR, X-ray crystal diffraction, CD and HR-ESI-MS. All compounds were tested for their antibacterial, antioxidant and cytotoxic activities, among these compounds, 5 showed cytotoxicity against MDA-MB-435 cell with an IC50 of 25.96 +/- 0.32 mu M.

引用

页码：2919 / 2925

页数：7

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