Theanine improves stress resistance in Caenorhabditis elegans

被引：22
|
作者：
Gong Yushun [1 ]
Luo Yunfeng [3 ]
Huang Jian-an [1 ]
Zhang Jianwei [2 ]
Peng Yuxuan [2 ]
Liu Zhonghua [2 ,4 ]
Zhao Baolu [3 ]
机构：
[1] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China
[2] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[4] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2012年 / 4卷 / 04期
基金：
美国国家科学基金会;
关键词：
Theanine; Caenorhabditis elegans; Stress resistance; Heat shock protein; UNIQUE AMINO-ACID; INCREASE LIFE-SPAN; TEA LEAVES; RATS; PATHWAYS; MEMORY; MICE;
D O I：
10.1016/j.jff.2012.04.005
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The beneficial effects of theanine in tea are reported on many aspects. Here we report that theanine can extend nematode Caenorhabditis elegans lifespan under stress. Theanine (100 mg/mL) significantly increased the mean longevity of C. elegans by 12.8% and 21.3% under heat stress and oxidative stress, respectively. However, theanine treatment did not increase survival of C. elegans under normal culture condition. Further studies showed that theanine mediated lifespan extension under heat stress was involved in heat shock protein-16.2 (HSP-16.2) up-regulating expression. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：988 / 993
页数：6
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