Catalysis of the Biginelli reaction by ferric and nickel chloride hexahydrates.: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

被引：281

作者：

Lu, J ^{[1
]}

Bai, YJ ^{[1
]}

机构：

[1] NW Univ Xian, Dept Chem, Shaanxi Prov Key Lab Physicoinorgan Chem, Xian 710069, Shaanxi, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2002年 / 04期

关键词：

Biginelli reaction; dihydropyrimidine-2(1H)-ones; nickel chloride hexahydrate; ferric chloride hexahydrate;

D O I：

10.1055/s-2002-20956

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3.4-dihydropyrimidinones from the aldehyde. beta-keto ester and urea in ethanol. using ferric chloride hexahydrate or nickel chloride hexahydrate as the catalyst, is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (53-97%) and short reaction time (4-5 hours).

引用

收藏

页码：466 / 470

页数：5

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