The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches

被引：166
作者：
Pandya, Pankita H. [1 ]
Murray, Mary E. [2 ]
Pollok, Karen E. [3 ]
Renbarger, Jamie L. [4 ]
机构：
[1] Indiana Univ Sch Med, Riley CCRC 2641,705 Riley Hosp Dr, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Riley CCRC 2623,705 Riley Hosp Dr, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Res Bldg R4,302D1044 West Walnut St, Indianapolis, IN 46202 USA
[4] Indiana Univ Sch Med, Riley CCRC 2616,705 Riley Hosp Dr, Indianapolis, IN 46202 USA
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷
关键词：
REGULATORY T-CELLS; DNA METHYLATION; IMMUNOTHERAPY; COMPLEMENT; MECHANISMS; RECEPTOR; ANGIOGENESIS; MOBILIZATION; ONCOLOGY; INSIGHTS;
D O I：
10.1155/2016/4273943
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interplay among immune activation and cancer pathogenesis provides the framework for a novel subspecialty known as immunooncology. In the rapidly evolving field of immunooncology, understanding the tumor-specific immune response enhances understanding of cancer resistance. This review highlights the fundamentals of incorporating precision medicine to discover new immune biomarkers and predictive signatures. Using a personalized approach may have a significant, positive impact on the use of oncolytics to better guide safer and more effective therapies.
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页数：13
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