Measurement of Disease Activity and Damage in Sjogren's Syndrome

被引：8

作者：

Vitali, Claudio ^{[1
,2
]}

机构：

[1] Villamarina Hosp, Dept Internal Med, Piombino, Italy

[2] Villamarina Hosp, Rheumatol Sect, Piombino, Italy

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2008年 / 34卷 / 04期

关键词：

Sjogren's syndrome; Disease activity; Disease damage; Outcome measures;

D O I：

10.1016/j.rdc.2008.08.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sjogren's syndrome (SS) is a systemic autoimmune disease that is characterized by an aggressive autoimmune response to epithelia, with consequent reduction of their secretions accompanied by sicca complaints. Systemic features may also be present in a subset of patients and may require more aggressive therapies. Improvements in knowledge concerning disease pathophysiology, combined with the availability of specifically targeted therapies able to modulate or block some of the most important pathologic mechanisms of the disease, may open totally new perspectives in the therapeutic approach to SS. The absence of reliable and validated outcome measures for SS is a major obstacle in performing clinical trials of new therapies in SS but studies devoted to defining outcome measurement instruments for this disorder have been performed or are in an advanced phases of completion.

引用

页码：963 / +

页数：10

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