The Nanomechanical Properties of Lipid Membranes are Significantly Influenced by the Presence of Ethanol

被引：55

作者：

Stetter, Frank W. S. ^{[1
]}

Hugel, Thorsten ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Phys, IMETUM, D-80290 Munich, Germany

来源：

BIOPHYSICAL JOURNAL | 2013年 / 104卷 / 05期

关键词：

SHORT-CHAIN ALCOHOLS; ATOMIC-FORCE; MECHANICAL-PROPERTIES; INTERFACIAL-TENSION; BILAYERS; STABILITY; AFM; AREA/MOLECULE; UNSATURATION; PERMEABILITY;

D O I：

10.1016/j.bpj.2013.01.021

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ethanol has a profound impact on biological systems and Is moreover used in various medical and nonmedical applications. Its interaction with the lipid part of biological membranes has been the subject of intensive studies, but surprisingly, to our knowledge, no study has examined the influence of ethanol on lipid bilayer nanomechanics. We performed atomic force microscopy-based measurements to assess the influence of ethanol on the nanomechanical properties of fluid supported lipid bilayers. Ethanol significantly reduces membrane stability, bilayer thickness, Young's modulus, area stretch modulus, and bending stiffness. Altogether, our data suggest that ethanol addition to supported lipid bilayers supports both the hydrophobic and the hydrophilic permeation pathways by a decrease of bilayer thickness and reduced stability, respectively.

引用

页码：1049 / 1055

页数：7

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