Nanolipoidal α-terpineol modulates quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa

被引：28
|
作者：
Bose, Sunil Kumar [1 ]
Nirbhavane, Pradip [2 ]
Batra, Mahak [3 ]
Chhibber, Sanjay [1 ]
Harjai, Kusum [1 ]
机构：
[1] Panjab Univ, Dept Microbiol, BMS Block 1, Chandigarh 160014, India
[2] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
[3] Panjab Univ, Ctr Syst Biol & Bioinformat, Chandigarh 160014, India
来源：
NANOMEDICINE | 2020年 / 15卷 / 18期
关键词：
alpha-terpineol; antivirulence; biofilms; nanoencapsulation; Pseudomonas aeruginosa; quorum sensing; NANOSTRUCTURED LIPID CARRIERS; ENCAPSULATED CHITOSAN NANOPARTICLES; ESSENTIAL OILS; INHIBITION; EFFICACY; ATTENUATION; CURCUMIN; DELIVERY; STRAINS; SYSTEMS;
D O I：
10.2217/nnm-2020-0134
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim:Pseudomonas aeruginosahas emerged as a major opportunistic pathogen meaning there is an immediate need to develop efficient antivirulence agents which offer a new class of superior therapeutics.Methods:Nanostructured lipid carriers (NLCs) containing alpha-terpineol (alpha T) were developed and characterized to determine expression profiles of quorum sensing regulated genes, antivirulence activity and antibiofilm effects againstP. aeruginosa.Results:The alpha T-NLCs had a size of 145.4 nm, polydispersity index of 0.242 and zeta-potential of -31.4 mV. They exhibited pronounced effects on the inhibition of quorum sensing mediated virulence and biofilm formation which were confirmed by molecular docking analysis and gene expression profiles.Conclusion:alpha T-NLCs show promise as effective antivirulence agents againstP. aeruginosain the postantibiotic era. [GRAPHICS] .
引用
收藏
页码：1743 / 1761
页数：19
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