The fluorinase from Streptomyces cattleya is also a chlorinase

被引：80
作者：
Deng, H
Cobb, SL
McEwan, AR
McGlinchey, RP
Naismith, JH
O'Hagan, D [1 ]
Robinson, DA
Spencer, JB
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Univ Cambridge, Chem Labs, Cambridge CB2 1EW, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 05期
基金：
英国生物技术与生命科学研究理事会;
关键词：
chlorinase; enzyme catalysis; fluorinase; halogenation; S-adenosylmethionine;
D O I：
10.1002/anie.200503582
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a C-F bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：759 / 762
页数：4
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