Total Synthesis of (±)-Maoecrystal V

被引：94

作者：

Peng, Feng ^{[1
]}

Danishefsky, Samuel J. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

[2] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10065 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 45期

关键词：

DIELS-ALDER REACTIONS; MAOECRYSTAL-V; CHIRAL OXAZABOROLIDINE; ASYMMETRIC-SYNTHESIS; CARBONYL-COMPOUNDS; EFFICIENT; OXYFUNCTIONALIZATION; REARRANGEMENT; HYDROCARBONS; CONVERSION;

D O I：

10.1021/ja309905j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of racemic maoecrystal V has been accomplished. Key steps include an intramolecular Diels-Alder cyclization to rapidly construct the core system from simple starting materials and the creation of the A-C ring transfusion through intramolecular delivery of a hydrogen to the hindered beta-face of the ring system.

引用

收藏

页码：18860 / 18867

页数：8

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