Two-Component In situ Forming Supramolecular Hydrogels as Advanced Biomaterials in Vitreous Body Surgery

被引：19

作者：

Boehm, Indra ^{[1
]}

Strotmann, Falko ^{[2
]}

Koopmans, Carsten ^{[1
]}

Wolf, Isabel ^{[2
]}

Galla, Hans-Joachim ^{[2
]}

Ritter, Helmut ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Organ Chem & Macromol Chem 2, D-40225 Dusseldorf, Germany

[2] Univ Munster, Inst Biochem, D-48149 Munster, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 04期

关键词：

biocompatibility; cell morphology; cyclodextrin; host-guest hydrogel; membrane interaction; vitreous body; HOST-GUEST INTERACTIONS; POLYMERS; COPOLYMERS;

D O I：

10.1002/mabi.201100357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polymeric beta-CD and poly{(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt)-co-[6-(acrylamido)-N-adamantylhexaneamide]} are synthesized to build in situ forming hydrogels based on host/guest interactions, so called physical hydrogels. The use of these hydrogels as a potential vitreous body substitute is discussed and recommended. Potential changes in cell morphology and cell vitality of the retinal ganglion cell line RGC-5 are determined. DSC experiments with artificial membrane structures are performed. The analyses show that beta-CD overrides the harmful effects of the highly toxic adamantyl-modified polymer. Although the final hydrogel is considered to be biocompatible, the application as a biomaterial has to be reconsidered.

引用

页码：432 / 437

页数：6

共 23 条

[1] THERMODYNAMIC AND STRUCTURAL EFFECTS OF PROPRANOLOL ON DPPC LIPOSOMES [J].

ALBERTINI, G ;

DONATI, C ;

PHADKE, RS ;

BOSSI, MGP ;

RUSTICHELLI, F .

CHEMISTRY AND PHYSICS OF LIPIDS, 1990, 55 (03) :331-337

[2]

Berridge MV, 2005, BIOTECHNOL ANN REV, V11, P127, DOI 10.1016/S1387-2656(05)11004-7

[3]

Bihonen R. L., 1993, CHEM PHYS LIPIDS, V64, P128

[4] Structural macromolecules and supramolecular organisation of the vitreous gel [J].

Bishop, PN .

PROGRESS IN RETINAL AND EYE RESEARCH, 2000, 19 (03) :323-344

[5] The use of hydrophilic polymers as artificial vitreous [J].

Chirila, TV ;

Hong, Y ;

Dalton, PD ;

Constable, IJ ;

Refojo, MF .

PROGRESS IN POLYMER SCIENCE, 1998, 23 (03) :475-508

[6] Formation of physical polymeric gels during polymerization of cyclodextrin complexed tert-butyl methacrylate in aqueous medium [J].

Choi, S ;

Ritter, H .

JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2005, A42 (03) :321-325

[7] Oscillatory shear experiments as criteria for potential vitreous substitutes [J].

Dalton, PD ;

Chirila, TV ;

Hong, Y ;

Jefferson, A .

POLYMER GELS AND NETWORKS, 1995, 3 (04) :429-444

[8] FUNCTION OF STEROLS IN MEMBRANES [J].

DEMEL, RA ;

DEKRUYFF, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 457 (02) :109-132

[9] Supramolecular drug-delivery systems based on polymeric core-shell architectures [J].

Haag, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (03) :278-282

[10] Formation of Physical Hydrogels via Host-Guest Interactions of β-Cyclodextrin Polymers and Copolymers Bearing Adamantyl Groups [J].

Koopmans, Carsten ;

Ritter, Helmut .

MACROMOLECULES, 2008, 41 (20) :7418-7422

← 1 2 3 →