LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGF-β1

被引：51
作者：
Miao, Feng [1 ]
Chen, Ji [1 ]
Shi, Meng [1 ]
Song, Yang [1 ]
Chen, Zhiming [1 ]
Pang, Liewen [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Thorac Surg, Shanghai 200040, Peoples R China
来源：
BIOSCIENCE REPORTS | 2019年 / 39卷
关键词：
CLINICAL-PRACTICE GUIDELINES; PROSTATE-CANCER; BETA; METASTASIS; DIAGNOSIS; CARCINOMA; PROMOTES; GROWTH;
D O I：
10.1042/BSR20181525
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
LncRNA HAND2-AS1 is characterized as a tumor suppressor involved in several types of malignancies, but its role in non-small cell lung cancer (NSCLC) is unknown. Our study was carried out to investigate the involvement of lncRNA HAND2-AS1 in NSCLC. In our study, we observed that levels of HAND2-AS1 were lower in tumor tissues than that in adjacent healthy tissues. Compared with healthy controls, plasma levels of HAND2-AS1 were lower, while levels of transforming growth factor beta (TGF-beta) were higher in NSCLC patients. A significant negative correlation between plasma levels of HAND2-AS1 and TGF-beta 1 was found in NSCLC patients but not in healthy controls. LncRNA HAND2-AS1 overexpression inhibits, while exogenous TGF-beta 1 treatment promotes cell migration and invasion ability and cancer cell stemness. Cancer cells with lncRNA HAND2-AS1 overexpression showed down-regulated TGF-beta 1, while TGF-beta 1 treatment showed no significant effects on lncRNA HAND2-AS1 expression. TGF-beta 1 attenuated the inhibitory effects of lncRNA HAND2-AS1 overexpression on cell migration, invasion and stemness. We concluded that lncRNA HAND2-AS1 may regulate the migration, invasion and stemness of NSCLC cells through interactions with TGF-beta 1.
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