Photosensitizer-Loaded pH-Responsive Hollow Gold Nanospheres for Single Light-Induced Photothermal/Photodynamic Therapy

被引：94
|
作者：
Yu, Meng [1 ]
Guo, Fang [1 ]
Wang, Jinping [1 ]
Tan, Fengping [1 ]
Li, Nan [1 ]
机构：
[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Drug Delivery & High Efficiency, Tianjin 300072, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 32期
关键词：
single-light inducement; triple response; one-step PTT/PDT effect; pH-driven targeting; phototriggered release; DRUG; DOXORUBICIN;
D O I：
10.1021/acsami.5b05763
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Novel photoinduced triple-response antitumor therapeutic system based on hollow gold nanospheres (HAuNS), pH (low) insertion peptide (pHLIP), and Chlorin e6 (Ce6), was reported for the first time. The system was able to intracellularly deliver the nanocarriers by the transmembrane ability of pHLIP at the condition of pH 6.2. Ce6 and pHLIP were then released from the surface of the carriers due to the weakening electrostatic interaction with HAuNS under the photoirradiation. Herein, HAuNS performed two different functions: (1) as a nanocarrier because of the excellent loading capability; (2) experienced the photothermal therapy (PTT) effect as a photothermal coupling agent (PTCA), thus enhancing the photodynamic therapy (PDT) effect of Ce6.
引用
收藏
页码：17592 / 17597
页数：6
相关论文
共 50 条
  • [1] Photosensitizer-loaded gold nanorods for near infrared photodynamic and photothermal cancer therapy
    Bhana, Saheel
    O'Connor, Ryan
    Johnson, Jermaine
    Ziebarth, Jesse D.
    Henderson, Luke
    Huang, Xiaohua
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 469 : 8 - 16
  • [2] A Photosensitizer-Loaded Polydopamine Nanomedicine Agent for Synergistic Photodynamic and Photothermal Therapy
    Yan, Shufeng
    Dong, Luying
    Hu, Ziyun
    Zhang, Yucheng
    Xu, Wei
    Xing, Jianhong
    Zhang, Juncheng
    MOLECULES, 2023, 28 (15):
  • [3] Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy
    Lin, Jing
    Wang, Shouju
    Huang, Peng
    Wang, Zhe
    Chen, Shouhui
    Niu, Gang
    Li, Wanwan
    He, Jie
    Cui, Daxiang
    Lu, Guangming
    Chen, Xiaoyuan
    Nie, Zhihong
    ACS NANO, 2013, 7 (06) : 5320 - 5329
  • [4] Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy
    Zhang, Xiaohan
    Li, Qiu
    Sun, Xiaodong
    Zhang, Baolei
    Kang, Hongxiang
    Zhang, Fuli
    Jin, Yiguang
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3 (06): : 1008 - 1016
  • [5] A light-induced nitric oxide controllable release nano-platform based on diketopyrrolopyrrole derivatives for pH-responsive photodynamic/photothermal synergistic cancer therapy
    Wang, Ya
    Huang, Xiaoyu
    Tang, Yunyun
    Zou, Jianhua
    Wang, Peng
    Zhang, Yewei
    Si, Weili
    Huang, Wei
    Dong, Xiaochen
    CHEMICAL SCIENCE, 2018, 9 (42) : 8103 - 8109
  • [6] Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles
    Ruijie Qian
    Kun Wang
    Yawen Guo
    Hongyan Li
    Ziyang Zhu
    Xiaojuan Huang
    Chengpeng Gong
    Yu Gao
    Rong Guo
    Biao Yang
    Chenyang Wang
    Dawei Jiang
    Xiaoli Lan
    Rui An
    Zairong Gao
    Journal of Nanobiotechnology, 20
  • [7] pH-responsive upconversion mesoporous silica nanospheres for combined multimodal diagnostic imaging and targeted photodynamic and photothermal cancer therapy
    Loganathan, Palanikumar
    Kalmouni, Mona
    Houhou, Tatiana
    Abdullah, Osama
    Ali, Liaqat
    Straubinger, Rainer
    Thomas, Sneha
    Afzal, Ahmed J.
    Barrera, Francisco N.
    Magzoub, Mazin M.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 436A - 436A
  • [8] pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy
    Palanikumar, L.
    Kalmouni, Mona
    Houhou, Tatiana
    Abdullah, Osama
    Ali, Liaqat
    Pasricha, Renu
    Straubinger, Rainer
    Thomas, Sneha
    Afzal, Ahmed Jawaad
    Barrera, Francisco N.
    Magzoub, Mazin
    ACS NANO, 2023, 17 (19) : 18979 - 18999
  • [9] Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles
    Qian, Ruijie
    Wang, Kun
    Guo, Yawen
    Li, Hongyan
    Zhu, Ziyang
    Huang, Xiaojuan
    Gong, Chengpeng
    Gao, Yu
    Guo, Rong
    Yang, Biao
    Wang, Chenyang
    Jiang, Dawei
    Lan, Xiaoli
    An, Rui
    Gao, Zairong
    JOURNAL OF NANOBIOTECHNOLOGY, 2022, 20 (01)
  • [10] Reversibly pH-responsive gold nanoparticles and their applications for photothermal cancer therapy
    Park, Sanghak
    Lee, Woo Jin
    Park, Sungmin
    Choi, Doowon
    Kim, Sungjee
    Park, Nokyoung
    SCIENTIFIC REPORTS, 2019, 9 (1)
12345