Alcohol intake and brain [3H]muscimol binding sites in alcohol-preferring and non-preferring rats

被引：0
作者：
Dyr, W
Siemiatkowski, M
Plaznik, A
Bidzinski, A
Kostowski, W
机构：
[1] Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland
[2] Inst Psychiat & Neurol, Dept Biochem, PL-02957 Warsaw, Poland
[3] Med Acad, Dept Pharmacol, PL-00927 Warsaw, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 1999年 / 51卷 / 02期
关键词：
H-3]muscimol; autoradiography; alcohol; alcohol-preferring rats; GABA-A receptors;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study has employed in vitro autoradiography to determine the distribution and density of [H-3]muscimol binding sites in the brains of alcohol high-preferring line of rats (WHP) and alcohol low-preferring line of rats (WLP). While the density of [H-3]muscimol binding was found to be similar in the frontal cortex, caudate-putamen, nucleus accumbens, lateral acid medial septum, the density of [H-3]muscimol binding was lower in cingulate cortex of alcohol low-preferring rats as compared to alcohol high preferring rats. Moreover, the density of muscimol binding site's within this area was positively correlated with the intensity of ethanol consumption.
引用
收藏
页码：119 / 123
页数：5
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