Syntheses, spectral, crystallographic, antimicrobial, and antioxidant studies of few Mannich bases

The newly synthesized Mannich bases were characterized in this study on the basis of UV-Vis, FT-IR, H-1 NMR, C-13 NMR, Mass spectroscopic techniques, and micro elemental analyses. The single crystal X-ray diffraction analysis on one of the Mannich bases 1-[anilino(phenyl)methyl] pyrrolidine-2,5-dione was also carried out. This compound crystallizes in the monoclinic system, space group P2(1)/c, with a = 15.4871(8) , b = 6.6637 (3) , c = 20.1544 (11) , beta = 109.403(2)A degrees, Z = 4 and V = 1961.83 (17) (3). Antibacterial study has been carried out on all the Mannich bases against a panel of antibacterial (Escherichia coli, Salmonella typhi, and Bacillus subtilis) and antifungal agents (Aspergillus oryzae and Aspergillus fumigates), using Penicillin, Streptomycin, and Amphotericin B as standards. The antioxidant activities of the Mannich bases were determined by measuring their reducing power, their ability to inhibit linoleic acid peroxidation, and 2,2-diphenyl-picrylhydrazyl (DPPH)'s radical scavenging activities. The synthesized compounds contain moderate antioxidant and antimicrobial activities.