Objective: Enlargement of the lateral ventricles is among the most frequently reported macroscopic brain structural changes in schizophrenia, although variable in extent and localization. The authors investigated whether ventricular enlargement is related to regionally specific volume loss. Method. High-resolution magnetic resonance imaging scans from 39 patients with schizophrenia were analyzed with deformation-based morphometry, a voxel-wise whole brain morphometric technique. Results: Significant negative correlations with the ventricle-brain ratio were found for voxels in the left and right thalamus and posterior putamen and in the left superior temporal gyrus and insula. Conclusions: Thalamic shrinkage, especially of medial nuclei and the adjacent striatum and insular cortex, appear to be important contributors to ventricular enlargement in schizophrenia.
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Gur, RE
;
Maany, V
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Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Maany, V
;
Mozley, D
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机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Mozley, D
;
Swanson, C
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Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Swanson, C
;
Bilker, W
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机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Bilker, W
;
Gur, RC
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机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Gur, RE
;
Maany, V
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Maany, V
;
Mozley, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Mozley, D
;
Swanson, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Swanson, C
;
Bilker, W
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA
Bilker, W
;
Gur, RC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USAUniv Penn, Med Ctr, Neuropsychiat Sect, Sch Med,Dept Psychiat,Mental Hlth Clin Res Ctr, Philadelphia, PA 19104 USA