Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex

被引:98
作者
Gaser, C
Nenadic, I
Buchsbaum, BR
Hazlett, EA
Buchsbaum, MS
机构
[1] Univ Jena, Dept Psychiat, D-07743 Jena, Germany
[2] Mt Sinai Sch Med, Dept Psychiat, Neurosci PET Lab, New York, NY USA
[3] NIMH, Clin Brain Disorders Branch, Bethesda, MD 20892 USA
关键词
D O I
10.1176/appi.ajp.161.1.154
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Enlargement of the lateral ventricles is among the most frequently reported macroscopic brain structural changes in schizophrenia, although variable in extent and localization. The authors investigated whether ventricular enlargement is related to regionally specific volume loss. Method. High-resolution magnetic resonance imaging scans from 39 patients with schizophrenia were analyzed with deformation-based morphometry, a voxel-wise whole brain morphometric technique. Results: Significant negative correlations with the ventricle-brain ratio were found for voxels in the left and right thalamus and posterior putamen and in the left superior temporal gyrus and insula. Conclusions: Thalamic shrinkage, especially of medial nuclei and the adjacent striatum and insular cortex, appear to be important contributors to ventricular enlargement in schizophrenia.
引用
收藏
页码:154 / 156
页数:3
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