Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

被引：78

作者：

Huang, Yubin ^{[1
]}

Xu, Zhen ^{[1
]}

Xiong, Shanshan ^{[1
]}

Qin, Guangrong ^{[2
]}

Sun, Fangfang ^{[1
]}

Yang, Jian ^{[3
]}

Yuan, Ti-Fei ^{[4
]}

Zhao, Lei ^{[1
]}

Wang, Ke ^{[5
]}

Liang, Yu-Xiang ^{[6
]}

Fu, Lin ^{[7
]}

Wu, Tianzhun ^{[1
]}

So, Kwok-Fai ^{[5
,6
]}

Rao, Yanxia ^{[3
]}

Peng, Bo ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China

[2] Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China

[3] Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 201108, Peoples R China

[5] Jinan Univ, Guangdong Hong Kong Macau Inst CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China

[6] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China

[7] Wenzhou Med Univ, Sch Ophthalmol & Optometry, Affiliated Eye Hosp, Wenzhou 325000, Zhejiang, Peoples R China

来源：

CELL DISCOVERY | 2018年 / 4卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CENTRAL-NERVOUS-SYSTEM; CILIARY EPITHELIAL-CELLS; STEM-CELLS; ADULT BRAIN; MAIN SOURCE; MACROPHAGES; MONOCYTES; MICE; REGENERATION; FATE;

D O I：

10.1038/s41421-018-0011-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Elucidating the origin of microglia is crucial for understanding their functions and homeostasis. Previous study has indicated that Nestin-positive progenitor cells differentiate into microglia and replenish the brain after depleting most brain microglia. Microglia have also shown the capacity to repopulate the retina after eliminating all retinal microglia. However, the origin(s) of repopulated retinal microglia is/are unknown. In this study, we aim to investigate the origins of repopulated microglia in the retina. Interestingly, we find that repopulated retinal microglia are not derived from Nestin-positive progenitor cells. Instead, they have two origins: the center-emerging microglia are derived from residual microglia in the optic nerve and the periphery-emerging microglia are derived from macrophages in the ciliary body/iris. Therefore, we have for the first time identified the extra-retinal origins of microglia in the adult mammalian retina by using a model of microglial repopulation, which may shed light on the target exploration of therapeutic interventions for retinal degenerative disorders.

引用

页数：16

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