Benchmarking of a checklist for the identification of familial risk for breast and ovarian cancers in a prospective cohort

被引：28

作者：

Rhiem, Kerstin ^{[1
]}

Buecker-Nott, Hans-Joachim ^{[2
]}

Hellmich, Martin ^{[3
]}

Fischer, Holger ^{[4
]}

Ataseven, Beyhan ^{[5
]}

Dittmer-Grabowski, Christine ^{[6
]}

Latos, Kunibert ^{[7
]}

Pelzer, Volker ^{[8
]}

Seifert, Manuela ^{[9
]}

Schmidt, Andrea ^{[10
]}

Rezek, Daniela ^{[11
]}

Groh, Ulrich ^{[12
]}

Meinerz, Wolfgang ^{[13
]}

Crommelinck, Dirk ^{[14
]}

Hahnen, Eric ^{[1
]}

Wesselmann, Simone ^{[15
]}

Schmutzler, Rita Katharina ^{[1
]}

机构：

[1] Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, CIO, Fac Med, Cologne, Germany

[2] Med Assoc Westphalia Lippe, Hagen, Germany

[3] Inst Med Stat & Computat Biol IMSB, Cologne, Germany

[4] Klin Senol Evangel Kliniken Gelsenkirchen, Gelsenkirchen, Germany

[5] Ludwig Maximilians Univ Munchen, Dept Obstet & Gynecol, Kliniken Essen Mitte, Gynakol,Univ Hosp, Munich, Germany

[6] Kliniken Essen Mitte, Senol, Essen, Germany

[7] Katharinen Hosp Unna, Klin Gynakol & Geburtshilfe, Unna, Germany

[8] Brustzentrum GFO Kliniken Bonn Betriebstatte St M, Bonn, Germany

[9] Stadt Klinikum Solingen, Abt Senol, Solingen, Germany

[10] Brustzentrum Muhlheim Oberhausen, Oberhausen, Germany

[11] Marien Hosp Wesel, Kooperat Brustzentrum, Wesel, Germany

[12] Brustzentrum Bad Nauheim, Bad Nauheim, Germany

[13] Brustzentrum Paderborn, Paderborn, Germany

[14] Brustzentrum Luisenkrankenhaus Aachen, Aachen, Germany

[15] German Canc Soc, Berlin, Germany

来源：

BREAST JOURNAL | 2019年 / 25卷 / 03期

关键词：

BRCA1; BRCA2; breast cancer; familial risk; genetic testing; BRCA1; WOMEN;

D O I：

10.1111/tbj.13257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The detection of deleterious germline mutations in BRCA1 and BRCA2 considerably influences the clinical management of healthy and diseased carriers. Therefore, the identification of persons at risk who could uptake genetic counseling and testing is pivotal. We developed a checklist with validated criteria to improve the identification, and prospectively evaluate the incidence, of familial cancer history in 5091 breast cancer patients. The rate of 30.4% of patients at high genetic risk underpins the demand for care in risk identification and counseling. The easy-to-use instrument promotes the implementation and dissemination of risk counseling by physicians.

引用

页码：455 / 460

页数：6

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