Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques

被引：52

作者：

Fatakdawala, Hussain ^{[1
]}

Poti, Shannon ^{[2
]}

Zhou, Feifei ^{[1
]}

Sun, Yang ^{[1
]}

Bec, Julien ^{[1
]}

Liu, Jing ^{[1
]}

Yankelevich, Diego R. ^{[1
,3
]}

Tinling, Steven P. ^{[3
]}

Gandour-Edwards, Regina F. ^{[4
]}

Farwell, D. Gregory ^{[2
]}

Marcu, Laura ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Otolaryngol, Sacramento, CA 95817 USA

[3] Univ Calif Davis, Dept Elect Engn, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Pathol & Lab Med, Sacramento, CA 95817 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2013年 / 4卷 / 09期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; TUMOR THICKNESS; GOLD NANOPARTICLES; PLASMON RESONANCE; PREDICTIVE-VALUE; CARCINOMA; DIAGNOSIS; SPECTROSCOPY; CAVITY; TIME;

D O I：

10.1364/BOE.4.001724

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology. (C) 2013 Optical Society of America

引用

页码：1724 / 1741

页数：18

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